EPIcx (epidemics in complex environments) is a research lab within the Pierre Louis Institute of Epidemiology and Public Health (UMR-S 1136) at INSERM and Université Pierre et Marie Curie, Faculty of Medicine, in Paris, France. We use mathematical models and computational thinking to study infectious disease epidemics in environments characterized by many degrees of complexity, as typically observed in reality. By integrating methods of complex systems with statistical physics approaches, computational sciences, mathematical epidemiology and geographic information systems, we focus on characterizing the conditions for the pathogen propagation and maintenance, quantifying the impact on the hosts population and testing a variety of intervention measures aimed at the epidemic control.